急性链球菌感染后肾小球肾炎研究进展

斑鸠菊注射液 http://pf.39.net/bdfyy/bdfzd/140226/4344158.html

国内外近年来在识别急性链球菌方面取得了丰富研究进展。肾炎相关链球菌纤溶酶及链球菌致外毒素等被发现与肾小球肾炎的发病密切相关。与健康人相比，急性链球菌感染之后肾小球肾炎患者被发现人类白细胞抗原等易感因素表达升高。另外可逆性后脑白质脑病与自身免疫性溶血性贫血均于急性链球菌感染导致的肾小球肾炎有着关联性。对该病的治疗目前仍以保守治疗为主，对不良反应需要积极的治疗才可达到良好的预后效果。对于严重的A族链球菌感染与急性链球菌感染为主的肾小球肾炎是导致死亡的重要原因之一。对于该病的机制研究与疫苗研制有了一定的进展。本研究对近年来国内外急性链球菌感染的肾小球肾炎的发病机制、临床多样性、宿主易感性、治疗最近进展进行综述。

Inrecentyears,domesticandforeignresearchhasmaderichresearchprogressinidentifyingacutestreptococcus.Nephritis-associatedStreptococcalplasminandStreptococcus-inducedexotoxinhavebeenfoundtobecloselyrelatedtothepathogenesisofglomerulonephritis.Comparedwiththehealthpeople,patientswithglomerulonephritisafteracuteStreptococcalinfectionwerefoundtohaveincreasedexpressionofsusceptibilityfactorssuchashumanleukocyteantigen.Inaddition,reversiblecerebralleukoencephalopathyandautoimmunehemolyticdysfunctionareassociatedwithglomerulonephritiscausedbyacuteStreptococcalinfection.Thetreatmentofthisdiseaseisstillbasedonconservativetreatment,anditrequiresapositivetreatmentforadversereactionstoachieveagoodprognosis.ForseveregroupAStreptococcalinfectionandacuteStreptococcalinfection,glomerulonephritisisoneoftheimportantcausesofdeath.Therehasbeensomeprogressinthemechanismresearchandvaccinedevelopmentofthedisease.Thisstudyreviewedthepathogenesis,clinicaldiversity,hostsusceptibilityandrecentprogressofglomerulonephritisinacutestreptococcusinfectioninrecentyears.

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